Cognition and Lewy body disease.
نویسندگان
چکیده
INTRODUCTION We're assisting in last years to an important change in clinical manifestations of Parkinson disease. Nowadays motor symptoms have best treatments if we compare with those existing some decades ago, which in last term, permits other manifestations being the main disabilities in an advanced Parkinson disease. Among these disabilities cognitives are the most severe due to it's prevalence and devastating consecuences. CLINICAL CASE We present the clinical case of a 72 aged woman who complains of cognitive and depressive symptoms, probably compatible with a depressive disorder, but finally diagnosed with Lewy body disease despite these cognitive manifestations are most common in advanced disease. CONCLUSIONS We' re showing an interesting case of Lewy body disease due to it's incipient symptomatology in cognitive manifestations (which makes it interesting for psichiatric value), motor manifestations (interesting for neurological value) and organic manifestations as complementary tests demostrate. Finally, we justificate the usage of rivastigmine as the choice of treatment in these cases which onset is mainly composed by cognitive symptoms. Key words: Parkinson, Lewy Bodies, dementia, cognitive impairment, rivastigmine, dopamine.
منابع مشابه
Uptake index of 123I-metaiodobenzylguanidine myocardial scintigraphy for diagnosing Lewy body disease
Objective(s): Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been used to evaluate cardiac sympathetic denervation in Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). The heart-tomediastinum ratio (H/M) in PD and DLB is significantly lower than that in Parkinson’s plus syndromes and Alzheimer’s disease. Although this ra...
متن کاملDevelopment of an 123I-metaiodobenzylguanidine Myocardial Three-Dimensional Quantification Method for the Diagnosis of Lewy Body Disease
Objective(s): We recently developed a new uptake index method for 123I-metaiodobenzylguanidine (123I-MIBG) heart uptake measurements by using planar images (radioisotope angiography and planar image) for the diagnosis of Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy bodies(DLB). However, the diagnostic accuracy of the uptake index was approximately equal to ...
متن کاملAlpha-synuclein induced apoptosis and proliferation interacted with CD44 in human lymphocytes
Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...
متن کاملAlpha-synuclein induced apoptosis and proliferation interacted with CD44 in human lymphocytes
Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...
متن کاملMEDICAL PRACTICE Lewy Body Dementia: Case Report and Discussion
Background: Lewy body dementia is a common but frequently underdiagnosed cause of dementia often mistaken for the more familiar entity of Alzheimer disease. Clinically the distinction is important, because it can have profound implications for management. Methods: The medical literature was searched using the keywords “Lewy bodies,” “Lewy body dementia,” “Alzheimer dementia,” and “parkinsonian ...
متن کاملAlterations in Olfaction during Alzheimer Disease, Parkinson Disease and Lewy Body Disease
Increasing interest is being shown in the link between olfaction, a complex sensory system, and cognition, particularly in the elderly. Olfaction is known to affect cognitive abilities and mood. In this article, we consider the impairment of olfactory function due to Alzheimer disease (AD), Parkinson disease (PD) and Lewy body disease (LBD), through pathological changes in the peripheral and ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Actas espanolas de psiquiatria
دوره 39 4 شماره
صفحات -
تاریخ انتشار 2011